{"id":16337,"date":"2025-12-16T07:43:55","date_gmt":"2025-12-16T07:43:55","guid":{"rendered":"https:\/\/www.epicmicron.com\/?post_type=astra-portfolio&#038;p=16337"},"modified":"2025-12-16T07:43:57","modified_gmt":"2025-12-16T07:43:57","slug":"metformin-api-jet-mill-grinding-production-line-in-russia","status":"publish","type":"astra-portfolio","link":"https:\/\/www.epicmicron.com\/pa\/cases\/metformin-api-jet-mill-grinding-production-line-in-russia\/","title":{"rendered":"\u0a30\u0a42\u0a38 \u0a35\u0a3f\u0a71\u0a1a \u0a2e\u0a48\u0a1f\u0a2b\u0a4b\u0a30\u0a2e\u0a3f\u0a28 \u0a0f\u0a2a\u0a40\u0a06\u0a08 \u0a1c\u0a48\u0a71\u0a1f \u0a2e\u0a3f\u0a71\u0a32 \u0a2a\u0a40\u0a38\u0a23 \u0a35\u0a3e\u0a32\u0a40 \u0a09\u0a24\u0a2a\u0a3e\u0a26\u0a28 \u0a32\u0a3e\u0a08\u0a28"},"content":{"rendered":"<h3 class=\"wp-block-heading\"><strong>1. \u0a15\u0a3e\u0a30\u0a1c\u0a15\u0a3e\u0a30\u0a40 \u0a38\u0a3e\u0a30<\/strong><\/h3>\n\n\n\n<p>A major pharmaceutical manufacturer specializing in diabetes medications needed to scale production of Metformin hydrochloride\u2014one of the world\u2019s most prescribed oral antidiabetic APIs. Their challenge: achieving consistent coarse micronization (D99 \u2264 150 \u03bcm) at an industrial throughput of 480 kg\/h, without compromising particle uniformity or process stability. Epic Powder\u2019s MQW20 Fluidized Bed Jet Mill was selected to replace their conventional metformin grinding system, resulting in enhanced control, higher yield, and reliable continuous operation.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"765\" src=\"https:\/\/www.epicmicron.com\/wp-content\/uploads\/2025\/07\/Jet-Mill-MQW40-P-1024x765.jpg\" alt=\"\u0a1c\u0a48\u0a71\u0a1f \u0a2e\u0a3f\u0a71\u0a32 MQW40\" class=\"wp-image-15536\" style=\"width:862px;height:auto\" srcset=\"https:\/\/www.epicmicron.com\/wp-content\/uploads\/2025\/07\/Jet-Mill-MQW40-P-1024x765.jpg 1024w, https:\/\/www.epicmicron.com\/wp-content\/uploads\/2025\/07\/Jet-Mill-MQW40-P-300x224.jpg 300w, https:\/\/www.epicmicron.com\/wp-content\/uploads\/2025\/07\/Jet-Mill-MQW40-P-768x574.jpg 768w, https:\/\/www.epicmicron.com\/wp-content\/uploads\/2025\/07\/Jet-Mill-MQW40-P-16x12.jpg 16w, https:\/\/www.epicmicron.com\/wp-content\/uploads\/2025\/07\/Jet-Mill-MQW40-P-600x448.jpg 600w, https:\/\/www.epicmicron.com\/wp-content\/uploads\/2025\/07\/Jet-Mill-MQW40-P.jpg 1520w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \u0a09\u0a24\u0a2a\u0a3e\u0a26\u0a28 \u0a1a\u0a41\u0a23\u0a4c\u0a24\u0a40<\/strong><\/h3>\n\n\n\n<p>\u0a2e\u0a48\u0a1f\u0a2b\u0a4b\u0a30\u0a2e\u0a3f\u0a28 \u0a26\u0a40 \u0a2a\u0a4d\u0a30\u0a2d\u0a3e\u0a35\u0a38\u0a3c\u0a40\u0a32\u0a24\u0a3e \u0a28\u0a3f\u0a2f\u0a70\u0a24\u0a30\u0a3f\u0a24 \u0a15\u0a23 \u0a06\u0a15\u0a3e\u0a30 \u0a35\u0a70\u0a21 &#039;\u0a24\u0a47 \u0a28\u0a3f\u0a30\u0a2d\u0a30 \u0a15\u0a30\u0a26\u0a40 \u0a39\u0a48 \u0a24\u0a3e\u0a02 \u0a1c\u0a4b \u0a05\u0a28\u0a41\u0a2e\u0a3e\u0a28\u0a2f\u0a4b\u0a17 \u0a2d\u0a70\u0a17 \u0a05\u0a24\u0a47 \u0a1c\u0a48\u0a35 \u0a09\u0a2a\u0a32\u0a2c\u0a27\u0a24\u0a3e \u0a28\u0a42\u0a70 \u0a2f\u0a15\u0a40\u0a28\u0a40 \u0a2c\u0a23\u0a3e\u0a07\u0a06 \u0a1c\u0a3e \u0a38\u0a15\u0a47\u0964 \u0a28\u0a3f\u0a30\u0a2e\u0a3e\u0a24\u0a3e \u0a28\u0a42\u0a70 \u0a38\u0a3e\u0a39\u0a2e\u0a23\u0a3e \u0a15\u0a30\u0a28\u0a3e \u0a2a\u0a3f\u0a06:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u0a25\u0a30\u0a42\u0a2a\u0a41\u0a71\u0a1f \u0a38\u0a40\u0a2e\u0a3e\u0a35\u0a3e\u0a02<\/strong> - \u0a2e\u0a4c\u0a1c\u0a42\u0a26\u0a3e \u0a09\u0a2a\u0a15\u0a30\u0a23 \u0a15\u0a23\u0a3e\u0a02 \u0a26\u0a47 \u0a06\u0a15\u0a3e\u0a30 \u0a26\u0a40 \u0a2a\u0a30\u0a3f\u0a35\u0a30\u0a24\u0a28\u0a38\u0a3c\u0a40\u0a32\u0a24\u0a3e \u0a24\u0a4b\u0a02 \u0a2c\u0a3f\u0a28\u0a3e\u0a02 \u0a1f\u0a3f\u0a15\u0a3e\u0a0a \u0a24\u0a4c\u0a30 &#039;\u0a24\u0a47 300 \u0a15\u0a3f\u0a32\u0a4b\u0a17\u0a4d\u0a30\u0a3e\u0a2e\/\u0a18\u0a70\u0a1f\u0a3e \u0a24\u0a4b\u0a02 \u0a35\u0a71\u0a27 \u0a28\u0a39\u0a40\u0a02 \u0a39\u0a4b \u0a38\u0a15\u0a26\u0a47\u0964<\/li>\n\n\n\n<li><strong>\u0a38\u0a3c\u0a41\u0a71\u0a27\u0a24\u0a3e \u0a26\u0a40\u0a06\u0a02 \u0a1c\u0a3c\u0a30\u0a42\u0a30\u0a24\u0a3e\u0a02<\/strong> - \u0a07\u0a71\u0a15 \u0a38\u0a16\u0a3c\u0a24 <strong>150 \u03bcm \u0a26\u0a3e D99<\/strong> \u0a2c\u0a48\u0a1a-\u0a1f\u0a42-\u0a2c\u0a48\u0a1a \u0a07\u0a15\u0a38\u0a3e\u0a30\u0a24\u0a3e \u0a2c\u0a23\u0a3e\u0a08 \u0a30\u0a71\u0a16\u0a23 \u0a32\u0a08 \u0a32\u0a4b\u0a5c\u0a40\u0a02\u0a26\u0a3e \u0a38\u0a40\u0964<\/li>\n\n\n\n<li><strong>\u0a35\u0a39\u0a3e\u0a05\u0a2f\u0a4b\u0a17\u0a24\u0a3e \u0a05\u0a24\u0a47 \u0a38\u0a70\u0a2d\u0a3e\u0a32<\/strong> - \u0a39\u0a3e\u0a08-\u0a38\u0a2a\u0a40\u0a21 \u0a1f\u0a47\u0a2c\u0a32\u0a47\u0a1f\u0a3f\u0a70\u0a17 \u0a32\u0a3e\u0a08\u0a28\u0a3e\u0a02 \u0a35\u0a3f\u0a71\u0a1a \u0a38\u0a3f\u0a71\u0a27\u0a47 \u0a38\u0a70\u0a15\u0a41\u0a1a\u0a28 \u0a32\u0a08 \u0a2e\u0a4b\u0a1f\u0a47, \u0a07\u0a15\u0a38\u0a3e\u0a30 \u0a15\u0a23 \u0a1c\u0a3c\u0a30\u0a42\u0a30\u0a40 \u0a38\u0a28\u0964<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. 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\u0a38\u0a4b\u0a32\u0a3f\u0a21 \u0a21\u0a4b\u0a1c\u0a3c API \u0a26\u0a47 \u0a09\u0a24\u0a2a\u0a3e\u0a26\u0a15\u0a3e\u0a02 \u0a32\u0a08, MQW20 \u0a17\u0a41\u0a23\u0a35\u0a71\u0a24\u0a3e \u0a28\u0a42\u0a70 \u0a15\u0a41\u0a30\u0a2c\u0a3e\u0a28 \u0a15\u0a40\u0a24\u0a47 \u0a2c\u0a3f\u0a28\u0a3e\u0a02 \u0a35\u0a27\u0a40 \u0a39\u0a4b\u0a08 \u0a38\u0a2e\u0a30\u0a71\u0a25\u0a3e \u0a32\u0a08 \u0a07\u0a71\u0a15 \u0a2d\u0a30\u0a4b\u0a38\u0a47\u0a2e\u0a70\u0a26, GMP-\u0a24\u0a3f\u0a06\u0a30 \u0a2e\u0a3e\u0a30\u0a17 \u0a26\u0a40 \u0a2a\u0a47\u0a38\u0a3c\u0a15\u0a38\u0a3c \u0a15\u0a30\u0a26\u0a3e \u0a39\u0a48\u0964<\/p>\n\n\n\n<p><strong>\u0a15\u0a40 \u0a24\u0a41\u0a38\u0a40\u0a02 \u0a06\u0a2a\u0a23\u0a40 API \u0a2e\u0a3f\u0a32\u0a3f\u0a70\u0a17 \u0a2a\u0a4d\u0a30\u0a15\u0a3f\u0a30\u0a3f\u0a06 \u0a28\u0a42\u0a70 \u0a38\u0a15\u0a47\u0a32 \u0a15\u0a30\u0a28 \u0a32\u0a08 \u0a24\u0a3f\u0a06\u0a30 \u0a39\u0a4b?<\/strong><br>\u0a38\u0a70\u0a2a\u0a30\u0a15 <a 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