A mid-sized pharmaceutical CDMO specializing in hormone-based APIs was looking for a jet mill in producing ultra-fine progesterone powder. It should meet strict particle size requirements for better bioavailability and formulation performance. Their existing milling equipment struggled with heat-sensitive materials like progesterone. It often results in inconsistent particle distribution, product degradation, and low throughput.
The client first learned about Epic Powder through a trusted industry contact. It’s a company in an adjacent sector that had successfully used our air classifier mills for several years. Impressed by the results and positive feedback from that reference, they reached out to explore whether our jet mill technology could solve their progesterone powder micronization needs.
After initial discussions and material testing at our facility, we recommended the MQP06 disc jet mill. The system’s fluid energy design, precise control, and fully enclosed, GMP-compliant construction were a perfect match for their heat-sensitive, high-value API.
During on-site trials with their own progesterone feedstock, the client was able to see the process in real time: no measurable temperature rise, virtually no product loss, and a clean, narrow particle size distribution that far exceeded their previous results. The operational simplicity and ease of cleaning also stood out—full CIP capability meant they could switch between batches quickly without risk of cross-contamination.
Once installed, the MQP06 integrated smoothly into their existing production line. Operators appreciated the intuitive HMI and the fact that the system required minimal parameter adjustment to hit target specifications day after day. Maintenance has been straightforward, and our remote support team has been responsive whenever fine-tuning was needed.
The client now runs progesterone micronization campaigns with confidence. Achieving consistent quality has strengthened their position with downstream formulation partners.
Key achieved parameters
Material: Progesterone
Particle size: d99 < 14 μm
Output: 20 kg/h
Equipment: Epic Powder MQP06 Disc Jet Mill